Ruthenium-catalyzed Reduction of Carbonyl Compounds Using Formic Acid
- 1 August 1982
- journal article
- research article
- Published by Oxford University Press (OUP) in Bulletin of the Chemical Society of Japan
- Vol. 55 (8) , 2441-2444
- https://doi.org/10.1246/bcsj.55.2441
Abstract
Carbonyl compounds were hydrogenated to the corresponding alcohols in excellent yields using formic acid with a ruthenium complex at 125 °C for 3 h. 2-Propanone was reduced to 2-propanol by RuCl2(PPh3)3–HCOOH system in 94% yield with 98% selectivity. 3-Pentanone, cyclohexanone, acetophenone, and propiophenone were hydrogenated to the corresponding alcohols in 86, 78, 84, and 86% yields respectively. The ketone having the bulkier alkyl groups showed lower reactivity. The catalytic activity was found to decrease in the order RuCl2(PPh3)3, RuHCl(PPh3)3, RuHCl(CO)(PPh3)3, and RuH2(PPh3)4.Keywords
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