BILIARY COLIC AS A MODEL FOR ASSESSING ANALGESIC ACTIVITY IN MAN

  • 1 January 1977
    • journal article
    • research article
    • Vol. 201  (2) , 444-449
Abstract
Acute pain from biliary colic is a model of pathological pain suitable for pharmacological investigations. It was found useful for assaying analgesic effect of a narcotic-type agent (pentazocine) and a non-narcotic drug (indoprofen), both given i.v. in a single dose. Differences in pain intensity scores assessed on a 5-point scale were taken as measurement of the pain-relieving effect. Distribution-free methods were used to estimate the potency ratio of the tested drugs. The analgesic potency of indoprofen based both on total and peak effect was roughly 1/10 that of pentazocine on a weight-for-weight basis. No adverse reactions were associated with indoprofen and a few were found after pentazocine.

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