PITUITARY REGULATION OF THYROID ACTIVITY

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Abstract
Under normal conditions, thyroid function is mainly controlled by the content of thyroid hormone in the plasma. If the level is too low, this acts as a stimulus for the pituitary production of thyrotropic hormone. If it is too high the opposite effect prevails. Administration of salicylate of dinitrophenol influences the thyroid function in a way which appears to contadict the existence of a regulating mechanism of this kind. However, evidence is presented which is consistent with the view that it is not the total content of thyroid hormone in the plasma, but its content of free, non-protein-bound thyroxine that regulates the pituitary effect on the thyroid.

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