What If There Are Only 30,000 Human Genes?
Top Cited Papers
- 16 February 2001
- journal article
- viewpoint
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 291 (5507) , 1255-1257
- https://doi.org/10.1126/science.1058969
Abstract
The complete assembly of the entire human genome sequence by Venter et al. confirms recent estimates that the total number of human protein coding genes might be less than 30,000--a mere one-third increase over the nematode Caenorhabditis elegans. Such a low gene number constitutes a paradigm change, which could drastically modify our understanding of organism complexity and evolution, as well as our current interpretation of transcriptome analyses. It may also have severe consequences on the long-term sustainability of the biomedical industry in the postgenomic era.This publication has 17 references indexed in Scilit:
- The Sequence of the Human GenomeScience, 2001
- Database resources of the National Center for Biotechnology InformationNucleic Acids Research, 2001
- Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogenNature, 2000
- Patterns of Variant Polyadenylation Signal Usage in Human GenesGenome Research, 2000
- The Genome Sequence of Drosophila melanogasterScience, 2000
- The End of the BeginningScience, 2000
- Discovery and modeling of transcriptional regulatory regionsPublished by Elsevier ,2000
- Genome Sequence of the Nematode C. elegans : A Platform for Investigating BiologyScience, 1998
- Stochastic mechanisms in gene expressionProceedings of the National Academy of Sciences, 1997
- Molecular Structure of Nucleic Acids: A Structure for Deoxyribose Nucleic AcidNature, 1953