Delivery of Tobramycin by Three Infusion Systems

Publisher Website
Google Scholar
Abstract
Delivery of tobramycin [an antibacterial agent] was studied at flow rates of 2, 4 and 6 ml/h after injection into the various sites of IVAC, IMED and Auto Syringe infusion systems. The actual times were markedly longer than the predicted times of delivery, especially for all sites of the IVAC system and the Buretrol site of the IMED system. Of tobramycin, .apprx. 20% was never delivered by the Buretrol sites of IVAC and IMED over 12 h at a flow rate of 2 ml/h. If tobramycin delivery is to be assured within 30 min after the start of infusion at 2-6 ml/h, the proximal y-site of IMED or Auto Syringe systems must be utilized. These data suggest the need for considering the method of tobramycin infusion when monitoring and interpreting its serum concentrations.