Serum Progesterone Before and After Human Chorionic Gonadotropin Injection Depends on the Estradiol Response to Ovarian Hyperstimulation During In Vitro Fertilization–Embryo Transfer Cycles
- 1 January 1999
- journal article
- Published by Springer Nature in Journal of Assisted Reproduction and Genetics
- Vol. 16 (5) , 242-246
- https://doi.org/10.1023/a:1020311328182
Abstract
Purpose: Our purpose was to assess if periovulatory serum progesterone is reflective of ovarian responsiveness in controlled ovarian hyperstimulation (COH). Methods: One-hundred forty-two in vitro fertilization–embryo transfer cycles in women using GnRH-a suppression and human menopausal gonadotropin (hMG) stimulation were evaluated. Responses were studied according to ovarian response to hMG and age. Outcome measures included peak serum estradiol, serum progesterone and estrogen/progesterone ratios on the day of hCG injection, number of harvested oocytes, fertilization rates, and delivered pregnancy rates. Results: A periovulatory rise in serum progesterone (>0.9 ng/ml) occurred only among younger women ( Conclusions: Periovulatory levels of serum progesterone vary according to ovarian response to COH. Elevations in progesterone do not appear to be a manifestation of poor responders. Reduced periovulatory progesterone may reflect inadequate steroidogenesis.Keywords
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