Development and reacquisition of tolerance to ethanol administered pre- and post-trial to rats
- 1 April 1981
- journal article
- Published by Springer Nature in Psychopharmacology
- Vol. 73 (2) , 165-167
- https://doi.org/10.1007/bf00429210
Abstract
The development of tolerance to the disruptive effects of ethanol on bar-pressing behavior was studied in rats by exposing them to four cycles of drug administration intercalated by 34-day drug-free periods. A negative correlation was obtained between the successive cycles and the number of sessions required for the rats to reach the criterion of tolerance. Also studied was the possible difference in the rate of development of tolerance in the four cycles when ethanol was administered before or after the task. One group of rats was required to perform the response under the influence of ethanol, while other group received the drug 90 min after the bar-pressing sessions. At the first cycle the group which performed under drug action developed tolerance more rapidly than the group which received ethanol after the task.Keywords
This publication has 9 references indexed in Scilit:
- Age-related differences in response to ethanol in the ratPhysiological Psychology, 1979
- Acquisition of behavioral tolerance to ethanol as a function of reinforced practice in ratsPsychopharmacology, 1979
- Accelerated development of tolerance during repeated cycles of ethanol exposurePsychopharmacology, 1978
- TOLERANCE AS ADAPTATION: INTERACTIONS WITH BEHAVIOR AND PARALLELS TO OTHER ADAPTIVE PROCESSESPublished by Elsevier ,1977
- Behavioral augmentation of tolerance to ethanol in the ratPsychopharmacology, 1973
- Tolerance to, and dependence on, some non-opiate psychotropic drugs.1971
- Acquisition and loss of tolerance to ethanol by the rat.1969
- A study of the alcohol-tolerance effect and an introduction of a new behavioural techniquePsychopharmacology, 1968
- Part 2. Psychophysiological FindingsQuarterly Journal of Studies on Alcohol, Supplement, 1964