Synthesis of Plasmepsin II Inhibitors – Potential Antimalarial Agents
Open Access
- 15 July 2003
- Vol. 8 (7) , 556-564
- https://doi.org/10.3390/80700556
Abstract
A new series of plasmepsin II (PM II) inhibitors has been prepared based on 4-aminopiperidine-tert-butyl-carbamate (1). These compounds might be useful as antimalarial drugs acting via a new mechanism, and therefore be less susceptible to parasite resistance now often observed with current antimalarial therapies. Some of the final compounds prepared exhibited encouraging inhibitory activity towards PM II.Keywords
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