Biotransformation of 10-Hydroxygeraniol and Related Compounds by a Cell Suspension Culture ofCatharanthus roseus: The Formation of Reduced Products
- 1 April 1985
- journal article
- research article
- Published by Georg Thieme Verlag KG in Planta Medica
- Vol. 51 (02) , 128-132
- https://doi.org/10.1055/s-2007-969426
Abstract
The biotransformation of 10-hydroxygeraniol and several closely related compounds by a cell suspension culture of Catharanthus roseus, employing a variety of protocols, was studied. The major products obtained from 10-hydroxygeraniol were: 10-hydroxylinalool, 10-hydroxy-citronellol, 7,8-dihydro-10-hydroxygeraniol, dihydrocitronellol, and 7,8-dihydro-10-hydroxylinalool. The relative proportions of products was dependent on the protocol used. Biotransformation of C-1 dideuterated 10-hydroxygeraniol led to the production of reduced products which were mono-deuterated. Biotransformation of 8-hydroxy-7,8-dihydrogeraniol afforded (-)-8-hydroxy-7,8-dihydrocitronellol while (+)-10-hydroxycitronellol was reduced to afford a mixture of diastereomers.Keywords
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