Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans
Open Access
- 14 January 2003
- journal article
- research article
- Published by Wiley in British Journal of Clinical Pharmacology
- Vol. 55 (1) , 51-61
- https://doi.org/10.1046/j.1365-2125.2003.01712.x
Abstract
Aims The cytochrome P450 enzyme CYP2C9 catalyses the 4′-hydroxylation of the nonsteroidal analgesic drug diclofenac in humans. We studied the influences of the known amino acid variants, CYP2C9*2 (Ar...Keywords
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