Early Plasmacytoid Dendritic Cell Changes Predict Plasma HIV Load Rebound during Primary Infection
- 15 November 2004
- journal article
- Published by Oxford University Press (OUP) in The Journal of Infectious Diseases
- Vol. 190 (10) , 1889-1892
- https://doi.org/10.1086/425020
Abstract
During human immunodeficiency virus (HIV) infection, interruption of highly active antiretroviral therapy (HAART) is usually followed by virus load rebound. Previous data have suggested a role for plasmacytoid dendritic cells (pDCs) in anti-HIV innate immunity. Here, the number of pDCs was measured by flow cytometry before, during, and after receipt of HAART in 7 patients with documented primary HIV-1 infection. A negative correlation was evidenced between pDC counts after 1 month of HAART and mean plasma virus load after interruption of HAART (r2 = 0.85; Spearman's partial ρ = −0.92; P = .03). pDC counts during treatment might help predict immune replication control after interruption of HAART.Keywords
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