Binding of Monoclonal Antibodies to Platelet Glycoproteins lb and llb/llla in Uremic Patients
- 1 January 1997
- journal article
- research article
- Published by S. Karger AG in Nephron
- Vol. 75 (3) , 283-285
- https://doi.org/10.1159/000189550
Abstract
In this study, we have found a reduced binding of monoclonal antibodies (CD42b and CD41a) to glycoproteins lb and Ilb/IIIa of uremic platelets. Presumably, this was due to the altered structure of the sugary part of these glycoproteins. Change in the glycoprotein composition may have effected the disturbed adhesion and aggregation of uremic platelets.Keywords
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