DNA minor groove binders as potential antitumor and antimicrobial agents
Top Cited Papers
- 7 April 2004
- journal article
- review article
- Published by Wiley in Medicinal Research Reviews
- Vol. 24 (4) , 475-528
- https://doi.org/10.1002/med.20000
Abstract
DNA minor groove binders constitute an important class of derivatives in anticancer therapy. Some of these compounds form noncovalent complexes with DNA (e.g., distamycin A, Hoechst 33258, and pentamidine) while others DNA‐binding compounds (such as CC‐1065) cause cleavages in the DNA backbone. In this article, we have reviewed the minor groove binders currently in preclinical evaluation in the last years. Diarylamidines such as DAPI, berenil, and pentamidine; bis‐benzimidazoles such as Hoechst 33258; ecteinascidins, pyrrololo [2,1‐c]‐[1,4]‐benzodiazepines (PBDs), CC‐1065, and distamycins are the classes discussed in this review article. A special section has been dedicated to hybrid molecules resulted by the combination of two minor groove binders, especially for derivatives of naturally occurring antitumor agents, such as anthramycin or the alkylating unit of the antibiotic CC‐1065, and distamycin frames. © 2004 Wiley Periodicals, Inc. Med Res Rev, 24, No. 4, 475–528, 2004Keywords
This publication has 198 references indexed in Scilit:
- Preparation of Benzene, Furan, and Thiophene Analogs of Duocarmycin SA Employing a Newly-Devised Phenol-Forming Reaction.CHEMICAL & PHARMACEUTICAL BULLETIN, 2000
- DNA Binding Properties of Novel Distamycin Analogs That Lack the Leading Amide Unit at the N-TerminusBiochemical and Biophysical Research Communications, 2000
- Synthesis and Cytotoxicity of Amino-seco-DSA: An Amino Analogue of the DNA Alkylating Agent Duocarmycin SAThe Journal of Organic Chemistry, 1999
- Synthesis of Furan and Thiophene Analogs of Duocarmycin SA.CHEMICAL & PHARMACEUTICAL BULLETIN, 1997
- DNA Sequence- and Structure-Selective Alkylation of Guanine N2 in the DNA Minor Groove by Ecteinascidin 743, a Potent Antitumor Compound from the Caribbean Tunicate Ecteinascidia turbinataBiochemistry, 1996
- Structure of a Covalent DNA Minor Groove Adduct with a Pyrrolobenzodiazepine Dimer: Evidence for Sequence-Specific Interstrand CrosslinkingJournal of Medicinal Chemistry, 1994
- Anti-HIV-I activity of linked lexitropsinsJournal of Medicinal Chemistry, 1992
- Structural analysis of d(GCAATTGC)2 and its complex with berenil by nuclear magnetic resonance spectroscopyBiochemistry, 1990
- Potentiation by phenylbisbenzimidazoles of cytotoxicity of anticancer drugs directed against topoisomerase IIEuropean Journal of Cancer and Clinical Oncology, 1990
- Generation of free radicals and lipid peroxidation by redox cycling of adriamycin and daunomycinBiochemical and Biophysical Research Communications, 1977