DETERMINANTS OF FECAL AND URINARY IRON EXCRETION IN DESFERRIOXAMINE-TREATED RATS

  • 1 January 1978
    • journal article
    • research article
    • Vol. 51  (3) , 415-423
Abstract
Radioiron excretion in the urine and feces after continuous s.c. infusion of desferrioxamine (DF) was studied in normal and hypertransfused rats in whom RES and parencymal Fe stores were labeled by selective 59Fe probes. The existence of 2 alternative pathways for the chelation of Fe in vivo by DF was indicated by the results. The 1st pathway was intracellular chelation in hepatocytes with chelated Fe excreted through the bile only. The 2nd pathway, which was extracellular, could only be activated after saturation of the transferrin FE binding capacity, with the chelated Fe excreted by the kidneys. The last mechanism was probably identical with the mode of action of diethylenetriaminepentaacetic acid (DTPA). [The possible use of DF in Fe overload diseases was discussed.].

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