Gingival Crevicular Fluid Matrix Metalloproteinase‐8 Levels Following Adjunctive Use of Meloxicam and Initial Phase of Periodontal Therapy

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Abstract
Background: The purpose of the present study was to assess the effects of adjunctive meloxicam on the matrix metalloproteinase‐8 (MMP‐8) levels of gingival crevicular fluid (GCF) in chronic periodontitis patients following the initial phase of periodontal therapy. Methods: Twelve chronic periodontitis patients received 7.5 mg meloxicam, and 10 patients received placebo tablets together with scaling and root planing in a 1 × 1 regimen for 10 days. Scaling and root planing were performed on day 3 of drug intake. The MMP‐8 levels in GCF samples obtained before and on day 10 of drug intake were determined by using the immunofluorescence assay. Plaque index (PI), papilla bleeding index (PBI), and GCF MMP‐8 levels were compared within each patient group, between the 2 patient groups, and also with a clinically healthy control group using non‐parametric statistical analyses. Results: Both meloxicam and placebo groups showed statistically significant reductions in PBI, PI, and GCF MMP‐8 levels on day 10 compared to baseline (P 0.05), while it was significantly higher in the placebo group (P J Periodontol 2002;73:103‐109.

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