Helicobacter pylori and gastrointestinal tract adenocarcinomas
Top Cited Papers
- 1 January 2002
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 2 (1) , 28-37
- https://doi.org/10.1038/nrc703
Abstract
Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.Keywords
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