Postalcoholic Lipemia in the Rat

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Abstract
After an overnight fast female Sprague-Dawley rats received by stomach tube 5 g of ethanol and 5 g of corn oil per kg of body weight; the corn oil contained trace amounts of triolein-1-14C. Ethanol was replaced isocalorically by glucose in control groups. Groups of 2 to 10 rats were sacrificed 2, 3, 4, 8 or 16 hr. after administration of the ethanol-corn-oil mixture; plasma and liver triglycerides, triglyceride specific activities and specific activities in lipid extracts of stomach and intestines were determined. Three hours after the meal, the animals receiving ethanol showed significantly reduced 14C activity of both plasma and liver triglycerides (p< .05); the triglyceride levels were similar to those of the controls. After 16 hr. the plasma and liver triglycerides in the ethanol group were 98.6[plus or minus].19.5 mg per 100 ml and 21.3[plus or minus]2.1 mg per g, respectively, as compared with 23.4+3.0 mg per 100 ml and 8.6+ 1.7 mg per g in the control group. The 14C specific activity of the liver triglyceride in the ethanol group was significantly lower than that in the controls. The data on 14C activity in the stomachs and intestine show that ethanol delayed absorption of corn oil from these organs: about 45% of the administered lipid dose was still present in the gastrointestinal tract 8 hr. after the meal, while practically no lipid radioactivity could be detected in the gastrointestinal tract of the controls. The results indicate that the delayed peaking in plasma triglyceride in animals receiving ethanol was probably due to temporary impairment of fat absorption from the digestive system. The increase in liver triglyceride accompanied by a decrease in their 14C activity suggest mobilization of endogenous lipids by ethanol.

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