Selective IgA deficiency and Crohn's disease: report of two cases.
Open Access
- 1 August 1977
- Vol. 18 (8) , 644-646
- https://doi.org/10.1136/gut.18.8.644
Abstract
Two patients are described with Crohn's disease and selective IgA deficiency. Serum IgA was undetectable in each case, and immunoperoxidase studies of the lamina propria showed a gross diminution of IgA-bearing plasma cells. Peripheral blood lymphocytes, however, showed normal numbers of IgA-bearing lymphocytes. The typical clinical course and histology in these two patients suggest that IgA-mediated responses in the mucosa are not involved in the pathogenesis of Crohn's disease.This publication has 15 references indexed in Scilit:
- Central failure of B-lymphocyte induction in pan-hypogammaglobulinemiaClinical Immunology and Immunopathology, 1975
- An immunoperoxidase technique for the identification of gastrin-producing cellsJournal of Clinical Pathology, 1974
- The plasma cells in inflammatory disease of the colon: A quantitative studyJournal of Clinical Pathology, 1974
- Immunoglobulin Deficiency and Regional EnteritisScandinavian Journal of Gastroenterology, 1972
- AGAMMAGLOBULINÆMIA WITH B LYMPHOCYTES SPECIFIC DEFECT OF PLASMA-CELL DIFFERENTIATIONThe Lancet, 1971
- SELECTIVE IgA DEFICIENCYMedicine, 1971
- The Liver in Crohn's DiseaseQJM: An International Journal of Medicine, 1971
- Serum concentration of 19 serum proteins in Crohn's disease and ulcerative colitisGut, 1971
- IMMUNE IMBALANCE IN DYSGAMMAGLOBULINÆEMIA TYPE IVThe Lancet, 1968
- Studies on the Serum γA-Globulin Level III. The Frequency of A-γA-GlobulinemiaScandinavian Journal of Clinical and Laboratory Investigation, 1965