A Safe, Economical Method for the Preparation of β-Oxo Esters
- 1 January 1993
- journal article
- research article
- Published by Georg Thieme Verlag KG in Synthesis
- Vol. 1993 (03) , 290-292
- https://doi.org/10.1055/s-1993-25849
Abstract
A high yield, economical method for preparation of ß-oxo esters has been developed involving the reaction of acid chlorides with potassium ethyl malonate using a magnesium chloride-triethylamine base system in either acetonitrile or ethyl acetate solvents. The method is suitable for the preparation of high purity ß-oxo esters in the laboratory and also in large scale production.Keywords
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