Total synthesis of (.+-.)-1-carbacefoxitin and -cefamandole and (.+-.)-1-oxacefamandole
- 1 April 1977
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 20 (4) , 551-556
- https://doi.org/10.1021/jm00214a018
Abstract
The total syntheses of the (.+-.)-1-carba analogues of cefoxitin, 7.alpha.-methoxydeacetylcephalothin and cefamandole and the (.+-.)-1-oxa analogue of cefamandole are described. Their bioactivity spectra against 14 typical organisms [bacteria] are similar to those of their natural 1-thia counterparts, with the 1-carba compounds somewhat less active and the 1-oxa compound more active than the natural ones.This publication has 1 reference indexed in Scilit:
- Deacetylcephalosporin CBiochemical Journal, 1961