Coronin-1 expression in T lymphocytes: insights into protein function during T cell development and activation.

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Abstract
Coronin has been described as an actin‐binding protein of Dictyostelium discoideum, and it has been demonstrated to play a role in cell migration, cytokinesis and phagocytosis. Coronin‐related proteins are found in many eukaryotic species, including Coronin‐1 in mammals whose expression is enriched in the hematopoietic tissues. Here, we characterize Coronin‐1 gene and protein expression in mouse embryonic and adult T lymphocytes. Coronin‐1 is expressed throughout T cell ontogeny and in peripheral αβ T cells. Expression varies along thymic cell development, with maximum levels observed in embryonic early thymocytes and, in the adults, the selected TCRαβ+ single‐positive thymocytes. Subcellular localization analysis indicates that Coronin‐1 is in equilibrium between the cytosol and the cell cortex, where it accumulates in F‐actin‐rich membrane protrusions induced by polarized activation of TCR–CD3‐stimulated T cells. These data are consistent with a role of Coronin‐1 in T cell differentiation/activation events involving membrane dynamisms and the cortical actin cytoskeleton.

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