Transgenic potato expressing Aβ reduce Aβ burden in Alzheimer's disease mouse model
Open Access
- 21 November 2005
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 579 (30) , 6737-6744
- https://doi.org/10.1016/j.febslet.2005.11.003
Abstract
Beta amyloid (Aβ) is believed one of the major pathogens of Alzheimer's disease (AD), and the reduction of Aβ is considered a primary therapeutic target. Immunization with Aβ can reduce Aβ burden and pathological features in transgenic AD model mice. Transgenic potato plants were made using genes encoding 5 tandem repeats of Aβ1–42 peptides with an ER retention signal. Amyloid precursor protein transgenic mice (Tg2576) fed with transgenic potato tubers with adjuvant showed a primary immune response and a partial reduction of Aβ burden in the brain. Thus, Aβ tandem repeats can be expressed in transgenic potato plants to form immunologically functional Aβ, and these potatoes has a potential to be used for the prevention and treatment of AD.Keywords
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