Modification of Testicular Steroid Metabolism in the Rat During Gonadotrophin Administration

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Abstract
The administration of human chorionic gonadotrophins to adult rats stimulates the formation of testosterone, 7α-hydroxy-testosterone and 5α-androstanediol in incubated testes. When the gonadotrophins are injected for several days, the testosterone formation is maintained at a high level; however, the transformation to 7α-hydroxy-testosterone decreases progressively to subcontrol levels, while 5α-androstanediol is produced in greater amounts.