EXPERIMENTAL STUDIES ON THE VITREOUS

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Abstract
CLINICAL experience and scattered experimental data indicate that diffusion in the vitreous is slow.1These observations were confirmed in systematic studies of Fischer2on diffusion of hemoglobin in arbitrarily divided samples of vitreous and in examinations on spreading of penicillin after intravitreal injection in the living eye.3New information on this subject was gained by Kinsey, Grant and Cogan4in determining the total movement of vitreous water, with deuterium oxide (heavy water; D2O) as a tracer substance. The authors concluded from their experiments that the movement of water in the rabbit vitreous was of a magnitude of about 85 cu. mm. per minute. Studies on the eye with radioactive sodium (Na24) autographs5provided instructive photographic imprints on diffusion of this normal body constituent in rabbit eyes under physiologic conditions. It was distributed homogeneously throughout the vitreous two to four hours after intraperitoneal

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