Effects of Epinephrine on the Normal, Hypertensive and Denervated Renal Vascular Systems in Man

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Abstract
Renal clearance studies were carried out on 7 normal subjects, 4 subjects with essential hypertension and 8 subjects with essential hypertension following bilateral Smithwick thoracolumbar sympathectomies. The continuous intraven. admn. of epinephrine causes a reduction in renal plasma flow of the normal, hypertensive, and sympathectomized patients proportional to the rate of infusion of epinephrine. Normal subjects show an increased rate of glomerular filtration and a decreased renal plasma flow as the rate of infusion of epinephrine is increased up to 300 [mu]g./hr. The sympathectomized patients show a progressive decrease of glomerular filtration with increasing epinephrine infusion. The filtration fraction increased in all types of patients with the increasing rate of infusion of epinephrine. There was no evidence that sympathectomy produced a hypersensitivity of the renal circulation to epinephrine.