Induction of Stomach Cancer in Rats and Mice by Halogenated Aliphatic Fumigants
- 1 December 1973
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Journal of the National Cancer Institute
- Vol. 51 (6) , 1993-1995
- https://doi.org/10.1093/jnci/51.6.1993
Abstract
Ethylene dibromide and 1,2-dibromo-3-chloropropane (DBCP) were administered to Osborne-Mendel rats and (C57BL × C3H)F1 mice via chronic oral intubation 5 times per week at experimentally predetermined maximally tolerated doses and at half those doses. As early as 10 weeks after initiation of treatment, both compounds induced a high incidence of squamous cell carcinomas of the stomach in both species. In addition, DBCP induced mammary adenocarcinomas in the female rats. Possible environmental hazards of these compounds are discussed.Keywords
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