The effects of intranasal insufflation of growth hormone releasing factor analogie GRF1 – 29 NH2 on growth hormone secretion in children with short stature

Publisher Website
Google Scholar
Abstract
The effects of intranasal insufflation of the synthetic growth hormone releasing factor GRF 1-29-NH2 on serum growth hormone (GH) were investigated in five healthy prepubertal children with short stature. 100 .mu.g/kg/body weight of synthetic GRF 1-29-NH2, 500 .mu.g in 100 .mu.l water, were insufflated intranasally after careful cleaning of the nose. GRF 1-29-NH2 induced a prompt rise of serum GH levels with peak values at 15 minutes in all children investigated. Peak serum GH values were 28.3 .+-. 12.0 ng/ml (.hivin.x, .+-. SD), range 17.1 - 47.6 ng/ml; .DELTA. GH was 27.0 .+-. 12.2 ng/ml (.hivin.x .+-. SD). Serum GH levels were still significantly raised 120 minutes after the insufflation of GRF 1-29-NH2 (p < 0.05). No side effects, except for burning of the nasal mucosa in one patient, were observed. The results of this study demonstrate that intranasal insufflation of synthetic GRF 1-29-NH2 induces a prompt release of GH in otherwise normal children with short stature. Pulsatile intranasal insufflation of GRF 1-29-NH2 probably could be used for the treatment of some children with GH deficiency due to a defect at a suprapituitary level.

This publication has 0 references indexed in Scilit: