A1‐, A2A‐ and A3‐subtype adenosine receptors modulate intraocular pressure in the mouse
- 1 September 2001
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 134 (2) , 241-245
- https://doi.org/10.1038/sj.bjp.0704267
Abstract
Despite the potential importance of the mouse in studying the pharmacology of aqueous dynamics, measurement of intraocular pressure (IOP) in its very small eye has been problematic. Utilizing a novel servo-null electrophysiologic approach recently applied to the mouse, we have identified a diversity of adenosine-receptor mechanisms in modulating IOP in this species. We report the first evidence that A(3) receptors increase IOP in any species, and verify in the mouse reports with larger mammals that A(1) receptors lower and A(2A) receptors increase IOP.Keywords
This publication has 20 references indexed in Scilit:
- Reliable measurement of mouse intraocular pressure by a servo-null micropipette system.2001
- Effects of rho-associated protein kinase inhibitor Y-27632 on intraocular pressure and outflow facility.2001
- Similarity of A3-adenosine and swelling-activated Cl− channels in nonpigmented ciliary epithelial cellsAmerican Journal of Physiology-Cell Physiology, 2000
- A3adenosine receptors regulate Cl−channels of nonpigmented ciliary epithelial cellsAmerican Journal of Physiology-Cell Physiology, 1999
- Synthesis, CoMFA Analysis, and Receptor Docking of 3,5-Diacyl-2,4-Dialkylpyridine Derivatives as Selective A3 Adenosine Receptor AntagonistsJournal of Medicinal Chemistry, 1999
- Comparative pharmacology of human adenosine receptor subtypes – characterization of stably transfected receptors in CHO cellsNaunyn-Schmiedebergs Archiv für experimentelle Pathologie und Pharmakologie, 1997
- Effects of Adenosine Agonists on Intraocular Pressure and Aqueous Humor Dynamics in Cynomolgus MonkeysExperimental Eye Research, 1997
- PD 116,948, a highly selective A1 adenosine receptor antagonistLife Sciences, 1987
- Ocular Penetration of Pilocarpine in PrimatesAmerican Journal of Ophthalmology, 1973