Improvements in the Preparation of Spin-Labeled Phosphorus Compounds of Potential Cytotoxicity
Open Access
- 1 January 1977
- journal article
- Published by Walter de Gruyter GmbH in Zeitschrift für Naturforschung B
- Vol. 32 (1) , 87-93
- https://doi.org/10.1515/znb-1977-0120
Abstract
The syntheses of spin-labeled phosphorus compounds containing the ethyleneimine, —N, and nitrogen mustard, —N(CH2CH2Cl)2, moieties were reinvestigated. By a judicious choice of solvents, stoichiometry, and reaction conditions yields of these compounds have been optimised. Thus, monoradical diamidates (5) and (9) wore prepared in 95 and 82% yields, respectively, and diradical monoamidates (7) and (12) were prepared in 95 and 45% yields, respectively. The nitrogen mustard derivative (16) was obtained in 92% yield. [xxx]Keywords
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