Malignancies, Prothrombotic Mutations, and the Risk of Venous Thrombosis

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Abstract
In 1868, Trousseau described the relationship between malignancy and venous thrombosis.1 Recent studies showed a 4% to 20% prevalence of malignancy in patients with deep venous thrombosis or pulmonary embolism.2,3 Although the risk of venous thrombosis in patients with cancer is evidently increased, studies that identify patients at highest risk of thrombosis are scarce. It is unclear what risks are for various types and stages of cancer.4,5