Effect of insulin on cardiac metabolism of intact normal dogs

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Abstract
The coronary sinus, pulmonary artery and aorta of intact normal dogs were catheterized and coronary blood flow (N2O desaturation method) cardiac output (Fick with O2) and myocardial O2, CO2, glucose, lactate and pyruvate extractions were determined. Measurements were repeated at intervals after an intravenous injection of insulin. Insulin caused a marked decrease in the myocardial threshold for glucose in normal dogs so that there resulted an increase in percentage extraction (A-V/A. 100) of glucose despite decreased arterial levels. This is in accord with the increased threshold for glucose previously observed in diabetic patients. The observations are consistent with the hypothesis that insulin facilitates the transfer of glucose into the cell. There was no significant change in the myocardial R. Q., a finding which was presumably due to the decreased blood glucose levels. Insulin did not alter the arterial levels, extraction or total utilization of lactate or pyruvate by the heart.

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