Acute cardiovascular changes following disoprofol

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Abstract
Summary: The acute cardiovascular changes following induction of anaesthesia with disoprofol 2 mg/kg have been studied in eight heavily premedicated patients with coronary artery disease. There was a significant increase in heart rate (+ 19%) and significant falls in mean arterial blood pressure (− 23%), peripheral vascular resistance (− 19%) and stroke volume (− 26%). Cardiac output did not change significantly. The extent and pattern of these changes are very similar to those seen after other intravenous induction agents.