CHANGES IN THE BASAL METABOLIC RATE ACCOMPANYING THE CONDITIONED STATE INDUCED BY MORPHINE

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Abstract
Increases in metabolism over the basal metabolic rate, greater than chance variations, accompanied the conditioned state induced in 5 dogs by morphine. The degree of increase varied from dog to dog. After allowing time for disappearance of the conditioned state, a 2nd or 3rd induced conditional state was accompanied by less increase over the basal metabolic rate. After removal in 3 dogs of one adrenal gland and denerva-tion of the other, no decrease in basal metabolic rate occurred during the control periods. During the conditioned state increases over the basal metabolic rate occurred as in normal dogs. Discharge of adrenalin seemed not to be a necessary factor in this increase.

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