VIABILITY AND MULTIPLICATION OF VACCINES IN IMMUNIZATION AGAINST TUBERCULOSIS

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Abstract
These workers have evaluated various antituberculous vaccines in mice. The length of time that animals survived after challenge infection served as a measure of immunity. They studied immunizing properties of viable and killed preparations, as well as multiplying and nonmultiplying vaccines. Viable vaccines were superior to killed vaccines. When the BCG vaccine was irradiated, the resulting immunity was in direct proportion to the number of viable cells remaining. BCG vaccines killed by heat or phenol were inferior to living bacterial suspensions.