Responses of the Rabbit and Cat Urinary Bladders in Situ to Drugs and to Nerve Stimulation

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Abstract
The response to atropine, hexamethonium, nicotine, emepronium bromide and some adrenergic compounds has been studied on the urinary bladder of the rabbit and the cat. It was shown that atropine caused a very small or no reduction in the response to electrically stimulated parasympathetic nerves in the urinary bladder of the rabbit. In the cat a dose dependent blockade was obtained after atropine administration. The stimulating response was abolished by hexamethonium or nicotine, suggesting that there are nicotinic receptors in the parasympathetic pathway. It is possible that the parasympathetic nerves running to the rabbit urinary bladder end in such nicotinic receptors on the effector cells in the detrusor muscle. Emepronium bromide, a potent anticholinergic compound, used clinically as a urological drug, was found to block the stimulatory response, which was interpreted as an effect on parasympathetic nicotinic receptors. Experiments with isoprenaline, adrenaline and noradrenaline showed that there are adrenergic α‐ and β‐receptors in the urinary bladder of the rabbit.