Polyadenylation of c-mos mRNA as a control point in Xenopus meiotic maturation
- 1 April 1995
- journal article
- Published by Springer Nature in Nature
- Vol. 374 (6522) , 511-516
- https://doi.org/10.1038/374511a0
Abstract
C-mos protein, encoded by a proto-oncogene, is essential for the meiotic maturation of frog oocytes. Polyadenylation of c-mos messenger RNA is shown here to be a pivotal regulatory step in meiotic maturation. Maturation is prevented by selective amputation of polyadenylation signals from c-mos mRNA. Injection of a prosthetic RNA, which restores c-mos polyadenylation signals by base pairing to the amputated mRNA, rescues maturation and can stimulate translation in trans. Prosthetic RNAs may provide a general strategy by which to alter patterns of mRNA expression in vivo.Keywords
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