ONTOGENY OF SUPPRESSOR CELLS II. SUPPRESSION OF GRAFT-VERSUS-HOST AND MIXED LEUKOCYTE CULTURE RESPONSES BY EMBRYONIC CELLS

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Abstract
Ontogenic development of suppressor cells was studied in mouse embryos. Liver cells of embryos at various stages of gestation were capable of interfering with the mixed leukocyte culture (MLC) reaction. The MLC reaction was inhibited by embryonic spleen and thymus cells. The latter were inhibitory only when originating in 16 and 17 day old embryos. Embryonic liver cells interfered with the graft vs. host (GVH) response induced in neonatal (BALB/c .times. C57BL)F1 or (C3H .times. C57BL)F1 mice by adult parental-type C57BL spleen cells. The effect was expressed in the mortality rates but was less pronounced in the splenomegaly reaction measured in vivo or in an in vitro test system. Suppression of the GVH mortality response was manifested predominantly when the liver cells were syngeneic with the effector cells. The MLC reaction was inhibited by liver cells syngeneic or allogeneic with the effector cells. The possible developmental patterns of these cells were discussed.