Local dental anesthesia with epinephrine. Minimal effects on the sympathetic nervous system or on hemodynamic variables

Publisher Website
Google Scholar
Abstract
To define the hemodynamic effects of local dental anesthesia, the mean arterial pressure (MAP), heart rate and plasma catecholamine responses were measured for 60 min following an inferior alveolar nerve block with epinephrine-and nonepinephrine-containing lidocaine hydrochloride anesthesia in 14 men using a randomized double-blind crossover trial. Lidocaine alone caused no significant change in MAP or heart rate and only slight, transient changes in plasma catecholamine concentrations when compared with baseline values. Lidocaine with epinephrine caused significant, sustained (60 min) increases in plasma epinephrine concentrations (mean 27 .+-. 4 to 94 .+-. 13 pg/ml) and a slight, but transient (2-min) increase in heart rate from 68 .+-. 3 to 70 .+-. 3 beats/min. Lidocaine with epinephrine caused no significant change in MAP. There is no significant hemodynamic response to licodaine dental anesthesia (with or without epinephrine) in healthy young men.