Effect of NGF antibodies on mast cell distribution, histamine and substance P levels in the knee joint of TNF-arthritic transgenic mice
- 1 March 1995
- journal article
- Published by Springer Nature in Rheumatology International
- Vol. 14 (6) , 249-252
- https://doi.org/10.1007/bf00262091
Abstract
We have previously shown an increase in nerve growth factor (NGF) levels and in mast cell (MC) distribution in the synovium of patients affected by rheumatoid arthritis. We now report that purified NGF antibodies injected into arthritic transgenic mice carrying the human tumour necrosis factor-α (TNF-α) gene caused reduction in the number of MCs, as well as a decrease in histamine and substance P levels within the synovium. These observations suggest that NGF antibody might be useful in studying the role of these pro-inflammtory markers in joint arthritis.Keywords
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