The Effect of Experimental Hydronephrosis on Clearance Data

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Abstract
Partial obstruction of one ureter was created in newborn rats and its effects were studied in the adult rat. The obstructed renal pelvis was found to be enlarged 2-3 times. The weight of the kidney on this side was 85% of the contralateral one. Inulin clearance was measured in a way, which allowed comparison between the conventional technique and a modified technique, designed to circumvent the dilution in the enlarged pelvis. With the conventional technique, filtration was 32% of that in the contralateral kidney, whereas with the new technique true filtration of the hydronephrotic kidney was 82% (p less than 0.001). The modified technique is evaluated and the implications of the functional results are discussed.