Liquid-chromatographic evaluation of age-related changes in the urinary excretion of free catecholamines in pediatric patients.
Open Access
- 1 February 1984
- journal article
- research article
- Published by Oxford University Press (OUP) in Clinical Chemistry
- Vol. 30 (2) , 301-303
- https://doi.org/10.1093/clinchem/30.2.301
Abstract
Pediatric patients (to age 18) without neuroblastoma show an age-related decrease in urinary excretion of each of the catecholamines--epinephrine, norepinephrine, and dopamine--in relation to creatinine excretion. From these data, I have developed reference intervals for pediatric age groups. Application of these ranges to seven patients with neuroblastoma and ganglioneuroblastoma indicated a high clinical sensitivity for the urinary dopamine determination but significant false-negative results for epinephrine and norepinephrine.Keywords
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