Stimulation of specific suppressor T cells in newborn responder mice by the terpolymer L‐glutamic acid60‐L‐alanine30‐L‐tyrosine10 (GAT)
- 1 September 1978
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 8 (9) , 615-620
- https://doi.org/10.1002/eji.1830080902
Abstract
The effects of immunization with the terpolymer of L‐glutamic acid60‐L‐alanine40‐L‐tyrosine10 (GAT), the copolymers of L‐glutamic acid60‐L‐alanine40 (GA) and of L‐glutamic acid50‐L‐tyrosine50 (GT), were compared in adult and newborn BALB/c and BALB.B mice. As expected, BALB/c (H‐2d) and BALB.B (H‐2b) adult mice were responders to GAT and GA and nonresponders to GT, which induced suppressor T cells in BALB/c but not in BALB.B mice. In contrast, newborn mice expressed different phenotypes. Two‐week‐old mice developed responses to GAT, GA and GT‐complexed methylated bovine serum albumin, but immunization at birth with these copolymers induced a cross‐reactive tolerance in both strains. Neonatal GAT tolerance could be transferred in adult and involved suppressor T cells in the two inbred strains, whereas the GT‐specific immune suppression was not demonstrable in newborn BALB/c mice. The significance of these data to our understanding of the regulation of specific immune response and tolerance is discussed.This publication has 14 references indexed in Scilit:
- Ly phenotype and mechanism of action of mouse neonatal suppressor T cells.The Journal of Experimental Medicine, 1977
- Genetic control of specific immune suppression. IV. Responsiveness to the random copolymer L-glutamic acid(50)-L-tyrosine(50) induced in BALB/c mice by cyclophosphamideThe Journal of Experimental Medicine, 1976
- Genetic control of specific immune suppression. II. H-2-linked dominant genetic control of immune suppression by the random copolymer L-glutamic acid50-L-tyrosine50 (GT).The Journal of Experimental Medicine, 1975
- Ontogeny of mouse lymphocyte function. II. Development of the ability to produce antibody is modulated by T lymphocytes.The Journal of Experimental Medicine, 1975
- GENETIC CONTROL OF IMMUNE RESPONSES IN VITROThe Journal of Experimental Medicine, 1974
- GENETIC CONTROL OF IMMUNE RESPONSES IN VITROThe Journal of Experimental Medicine, 1974
- MATURATION OF THE HUMORAL IMMUNE RESPONSE IN MICEThe Journal of Experimental Medicine, 1974
- Histocompatibility-Linked Immune Response GenesScience, 1972
- IMMUNE RESPONSES IN VITROThe Journal of Experimental Medicine, 1971
- Fractionation of nucleic acids with the methylated albumin columnJournal of Molecular Biology, 1962