ELECTRICALLY‐EVOKED RELEASE OF [3H]‐HISTAMINE FROM THE GUINEA‐PIG HYPOTHALAMUS
Open Access
- 1 December 1980
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 70 (4) , 555-560
- https://doi.org/10.1111/j.1476-5381.1980.tb09774.x
Abstract
1 [3H]-histamine was taken up by slices of guinea-pig hypothalamus against a concentration gradient. 2 Electrical field stimulation of the superfused slices resulted in an increased efflux of radioactivity, the major part of which was shown to be associated with histamine by paper chromatography. 3 The evoked release of histamine was dependent on calcium ions in the superfusate and was increased by 56% when the frequency of stimulation was doubled from 5 to 10 Hz.Keywords
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