PHASE-II RANDOMIZED STUDY OF DOXORUBICIN, VINCRISTINE, AND 5-FU VERSUS CYCLOPHOSPHAMIDE IN ADVANCED SQUAMOUS-CELL CARCINOMA OF THE CERVIX

  • 1 January 1981
    • journal article
    • research article
    • Vol. 65  (9-10) , 901-903
Abstract
Sixty-one evaluable patients with advanced squamous cell carcinoma of the cervix were treated in a randomized fashion with doxorubicin, vincristine and 5-FU [5-fluorouracil] in combination (AVF) or with cyclophosphamide (CTX). Of 31 patients treated with AVF, only 3 (10%) responded (1 complete response and 2 partial responses). Of 30 patients treated with CTX, there were 2 (7%) with partial responses. Two patients responded to AVF after failing CTX; 1 patient responded to CTX after failing AVF. Neither of these regimens was predictably useful in this patient population.