Chronic Myelocytic Leukaemia: a Pluripotent Haemopoietic Cell is Involved in the Malignant Clone

Publisher Website
Google Scholar
Abstract
Hemopoietic cells with pluripotent capabilities were grown in soft-gel cultures from the peripheral blood of a glucose-6-phoshate dehydrogenase (G6PD) electrophoretic A,B heterozygous [human] female with chronic myelocytic leukemia (CML). The cells produced mixed colonies composed of erythrocytic and granulocytic progeny. Only type B isoenzyme of G6PD was found in mixed colonies, in mature neutrophils, erythrocytes and committed granulocyte and erythrocyte stem cells. The fibroblasts of the patient contained both A and B isoenzymes of G6PD. Direct evidence was provided that a pluripotent hemopoietic stem cell is involved in the malignant clone in CML.