Localized 1H NMR measurements of gamma-aminobutyric acid in human brain in vivo.
- 15 June 1993
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 90 (12) , 5662-5666
- https://doi.org/10.1073/pnas.90.12.5662
Abstract
Localized 1H NMR spectroscopy in conjunction with J editing was used to measure the concentration of gamma-aminobutyric acid (GABA) in the occipital lobe of four control human volunteers and four epileptic volunteers who were receiving the drug vigabatrin. The GABA concentration measured in four nonepileptic subjects was 1.1 +/- 0.1 mumol/cm3 of brain, which is in good agreement with previous values measured in surgically removed human cortex. A dose-dependent elevation of GABA concentration was measured in patients receiving the GABA transaminase inhibitor vigabatrin, with the maximum measured level of 3.7 mumol/cm3 of brain measured at the highest dose (6 g per day) studied. 1H NMR measurements of GABA in those patients receiving GABA-elevating agents such as vigabatrin will be of importance in establishing the relationship between seizure suppression and the concentration of brain GABA.Keywords
This publication has 39 references indexed in Scilit:
- Detection and assignment of the glucose signal in 1h nmr difference spectra of the human brainMagnetic Resonance in Medicine, 1992
- Localized 1H NMR spectra of glutamate in the human brainMagnetic Resonance in Medicine, 1992
- Assignment of resonances in the 1H spectrum of rat brain by two‐dimensional shift correlated and j‐resolved NMR spectroscopyMagnetic Resonance in Medicine, 1991
- Detection of metabolic heterogeneity of human intracranial tumors in vivo by 1h nmr spectroscopic imagingMagnetic Resonance in Medicine, 1990
- Surface coil single-pulse localizationin vivo via inhomogeneous surface spoiling magnetic gradientNMR in Biomedicine, 1989
- Selective population inversion in NMRNature, 1984
- Anticonvulsant activity of the glial-selective GABA uptake inhibitor, THPONeuropharmacology, 1983
- Influence of inhibitors of the high affinity GABA uptake on seizure thresholds in miceNeuropharmacology, 1979
- DIVERSITY OF METABOLIC PATTERNS IN HUMAN BRAIN TUMORS—I. HIGH ENERGY PHOSPHATE COMPOUNDS AND BASIC COMPOSITION1Journal of Neurochemistry, 1977
- 4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian BrainEuropean Journal of Biochemistry, 1977