Anti-HIV and anti-HCMV Activities of New Aurintricarboxylic Acid Analogues
Open Access
- 24 June 1995
- journal article
- research article
- Published by SAGE Publications in Antiviral Chemistry and Chemotherapy
- Vol. 6 (3) , 179-186
- https://doi.org/10.1177/095632029500600307
Abstract
A variety of aurintricarboxylic acid (ATA) polymer analogues were prepared by substituting certain salicylic acid derivatives and carbonyl compounds for salicylic acid and formaldehyde in the ATA polymerization reaction. The new polymers were evaluated for prevention of the cytopathic effects of human immunodeficiency virus (HIV-1 and HIV-2) in MT-4 cell culture, HIV-1 in CEM cell culture, and human cytomegalovirus (HCMV) in HEL cell culture. The abilities of the analogues to inhibit syncytium formation between HIV-1- or HIV-2-infected HUT-78 cells and uninfected MOLT-4 cells were also evaluated. Several of the new analogues were found to be equipotent with ATA and dextran sulfate against HIV-1, HIV-2 and HCMV. The anti-HIV potencies of the new substances paralleled their activities against HCMV. The antiviral activities of the new analogues probably result from inhibition of virion binding to the cell membrane.Keywords
This publication has 26 references indexed in Scilit:
- Design and synthesis of cosalane, a novel anti-HIV agentBioorganic & Medicinal Chemistry Letters, 1993
- Synthesis and anti-HIV activities of low molecular weight aurintricarboxylic acid fragments and related compoundsJournal of Medicinal Chemistry, 1991
- Preparation and anti-HIV activities of aurintricarboxylic acid fractions and analogs: direct correlation of antiviral potency with molecular weightJournal of Medicinal Chemistry, 1991
- Serum beta2-microglobulin level increases in HIV infectionAIDS, 1990
- Highly specific inhibition of human immunodeficiency virus type 1 by a novel 6-substituted acyclouridine derivativeBiochemical and Biophysical Research Communications, 1989
- Syncytium Formation and Destruction of Bystander CD4+ Cells Cocultured with T Cells Persistently Infected with Human Immunodeficiency Virus as Demonstrated by Flow CytometryJournal of General Virology, 1989
- New Soluble-Formazan Assay for HIV-1 Cytopathic Effects: Application to High-Flux Screening of Synthetic and Natural Products for AIDS-Antiviral ActivityJNCI Journal of the National Cancer Institute, 1989
- Inhibitory effect of dextran sulfate and heparin on the replication of human immunodeficiency virus (HIV) in vitroAntiviral Research, 1987
- Aurintricarboxylic acid and evans blue represent two different classes of anionic compounds which selectively inhibit the cytopathogenicity of human T-cell lymphotropic virus type III/lymphadenopathy-associated virusBiochemical and Biophysical Research Communications, 1986
- Ueber Oxyaurine und OxyaurincarbonsäurenEuropean Journal of Inorganic Chemistry, 1892