Reduction of Iodine Transfer to Milk of Cows after Perchlorate Ingestion

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Abstract
These experiments quantitate the rela= tion between amount of perchlorate in- gested and radioiodine transferred to milk of the cow when radioiodine is fed daily or after radioiodine administration ceases. When radioiodine was given daily, graded doses of perchlorate, from 10 to 4,000 mg/day, increased plasma iodine in accord with Y = 88.1 X "°52. (Y = $g of control value and X is the daily dose of perchlorate in milligrams.) Curves for iodine-125 in milk and ratio of milk to plasma iodine-125 between the limits of 50 and 1,000 mg perchlorate daily were fitted by Y = 794.8 X -.~z5 and Y = 1,046.5 X-.6o~; these same curves be- tween 10 and 50 mg perchlorate daily were fitted by Y = 85.6 + .37 X and Y = 82.3 + .28 X. Between 1,000 and 4,000 mg perchlorate, these curves had a slope of 0. These data indicate that perchlorate can inhibit the iodide-transfer mechanism of the mammary gland of the cow and that a ratio of milk to iodine of .2 indicates complete blockage of this transfer.