Activation of Distinct T Cell Subsets Involved in IgM Antibody Response of Mice by Pertussis Toxin from Bordetella pertussis Strain Maeno
- 1 January 1984
- journal article
- research article
- Published by S. Karger AG in International Archives of Allergy and Immunology
- Vol. 75 (2) , 132-138
- https://doi.org/10.1159/000233603
Abstract
T cell activation mechanisms in the spleen induced by pertussis toxin (PT) were investigated. The degree of T cell activation was judged from results of helper activity assessed by measuring the in vitro anti-trinitrophenyl (TNP) IgM antibody response. When mice were injected intraperitoneally with 4 × 105 sheep erythrocytes (SRBC) and concomitantly given an intravenous injection with 10 µg of PT 4 days previously, significant generation of nonspecific helper T cells was observed unless primed T cells were stimulated in vitro with TNP-SRBC. Stimulation with TNP-SRBC resulted in marked suppression of helper activity because it induced generation of suppressor T cells specific for the carrier antigen.Keywords
This publication has 1 reference indexed in Scilit:
- Antitrinitrophenyl (TNP) Plaque Assay. Primary Response of Balb/c Mice to Soluble and Particulate ImmunogenExperimental Biology and Medicine, 1969