Using Drosophila melanogaster to map human cancer pathways
- 20 July 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Cancer
- Vol. 5 (8) , 626-639
- https://doi.org/10.1038/nrc1671
Abstract
The development of human cancer is a multistep process, involving the cooperation of mutations in signalling, cell-cycle and cell-death pathways, as well as interactions between the tumour and the tumour microenvironment. To dissect the steps of tumorigenesis, simple animal models are needed. This article discusses the use of the genetically amenable, multicellular organism, the vinegar fly Drosophila melanogaster. In particular, recent studies have highlighted the power of D. melanogaster for examining cooperative interactions between tumour suppressors and oncogenes and for generating in vivo models of tumour development and metastasis.Keywords
This publication has 147 references indexed in Scilit:
- Apoptotic Cells Can Induce Compensatory Cell Proliferation through the JNK and the Wingless Signaling PathwaysPublished by Elsevier ,2004
- Compensatory Proliferation Induced by Cell Death in the Drosophila Wing Disc Requires Activity of the Apical Cell Death Caspase Dronc in a Nonapoptotic RoleCurrent Biology, 2004
- dMyc Transforms Cells into Super-CompetitorsPublished by Elsevier ,2004
- Drosophila Myc Regulates Organ Size by Inducing Cell CompetitionPublished by Elsevier ,2004
- Border-cell migration: the race is onNature Reviews Molecular Cell Biology, 2003
- Cells compete for Decapentaplegic survival factor to prevent apoptosis in Drosophila wing developmentNature, 2002
- Drosophila's Insulin/PI3-Kinase Pathway Coordinates Cellular Metabolism with Nutritional ConditionsDevelopmental Cell, 2002
- The Hallmarks of CancerCell, 2000
- Coordination of Growth and Cell Division in the Drosophila WingCell, 1998
- Drosophila homologs of baculovirus inhibitor of apoptosis proteins function to block cell deathCell, 1995